Respiratory Medicine Expert: Dr Felix Chua

Royal Brompton Hospital - Tuesdays.

Dr. Felix Chua graduated from the University of London with undergraduate prizes and a university distinction.

He undertook postgraduate training in Respiratory and General (Internal) medicine at, amongst others, the Hammersmith Hospital, the Royal Brompton Hospital and University College London Hospital.

As part of his higher specialist training, he was awarded a Wellcome Research Training Fellowship to complete a PhD investigating pathobiological mechanisms that lead to pulmonary fibrosis (lung scarring).

He was first appointed as a consultant Respiratory and General Medicine physician at St. George’s Hospital NHS Trust in 2007. He joined the ILD department at Royal Brompton Hospital as a consultant in 2014.

Although his practice covers many aspects of Respiratory medicine, he has particular clinical expertise in common and unusual forms of interstitial lung diseases (ILD) including idiopathic and autoimmune (connective tissue disease-associated) forms, lung infections including pneumonia and tuberculosis (TB), bronchiectasis, asthma as well as smoking-related lung conditions including COPD and smokers’ bronchiolitis.

Dr. Chua lectures on his focus areas and is actively involved in undergraduate and postgraduate teaching. He is a member of various professional and specialist bodies, and conducts as well as supervises research into interstitial lung diseases and lung sepsis, original work that he presents at national and international meetings.

He is married to a cardiologist and has a young son.

• Chua F, Higton A, Colebatch A, O’Reilly K, Grubnic S, Vlahos I, Edwards CJ, Kiely PD. Idiopathic inflammatory myositis-associated ILD: ethnicity differences and lung function trends in a British cohort. Rheumatology (Oxford) 51(10): 1870-1876, 2012.
• Nair A, Godoy MCB, Holden AL, Madden BP, Chua F, Ost D, Roos J, Naidich DP and Vlahos I. Multi-detector CT and post-processing in planning and assisting bronchoscopic minimally invasive airway interventions. Radiographics. 32 (5): E201-32, 2012.
• Arulkumaran N, Suleman R, Cecconi M, Kiely P, Chua F. Rituximab-associated pneumonitis in ANCA-associated vasculitis. J Clin Rheumatol 18(1): 39-41, 2012.
• Kumar N, Bazari F, Rhodes A, Chua F, Tinwell B. Chronic Pneumocystis jiroveci presenting as asymptomatic granulomatous pulmonary nodules in lymphoma. J Infect 62: 484-6, 2011.
• Bicanic T, Solomon AW, Karunaharan N, Chua F, Pope C, Pond M, Herman J, Loyse A, Harrison T, Wansbrough-Jones M. Positive predictive value of the UK clinical case definition for H1N1/09 (‘swine’) influenza. J Infection 60: 405-407, 2010.
• Chaturvedi RR, Herron T, Simmons R, Shore D, Kumar P, Sethia B, Chua F, Vassiliadis E, Kentish JC. Passive stiffness of myocardium from congenital heart disease and implications for diastole. Circulation 121: 979-988, 2010.
• Chua F, Groth J. Investigation of the patient with pleural effusion. Letter. Clin Med 9(4): 400, 2009.
• Chua F, Dunsmore SE, Clingen PH, Mutsaers SE, Shapiro SD, Segal AW, Roes J and Laurent GJ. Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. American Journal of Pathology 170(1): 65-74, 2007.
• Chua F and Lai D. Acute Severe Asthma: Triage, Treatment and Thereafter. Current Anaesthesia & Critical Care 18(2): 61-68, 2007.
• Chua F and Laurent GJ. Neutrophil Elastase: Mediator of Both Extracellular Matrix Destruction and Accumulation. 21st Transatlantic Airway Conference. Proceedings of the American Thoracic Society 3(5): 424-427, 2006.
• Chua F, Gauldie J, Laurent GJ. Pulmonary Fibrosis: Searching for Model Answers. American Journal of Respiratory Cellular and Molecular Biology 33(1): 9-13, 2005.
• Chua F, Sly PD and Laurent GJ. State-of-the-art review: Pediatric Lung Diseases: From Proteinases to Pulmonary Fibrosis. Pediatric Pulmonology 39(5): 392-401, 2005.
• Chua F*, Atzori L*, Dunsmore SE, Willis D, Barbarisi M, McAnulty RJ and Laurent GJ. Attenuation of bleomycin-induced pulmonary fibrosis by the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol. Thorax 59: 217-223, 2004. (* joint authors)
• Chua F, Bellingan GJ. Acute Respiratory Distress Syndrome: Fibrosis Fast and Furious. Clinical Intensive Care 13(2): 65-72, 2002.
• Islam F, Chua F, Gillespie S, Jarmulowicz M, Lipman M. Respiratory and cutaneous manifestations of disseminated crytococcosis in AIDS. Sex Trans Infect 77: 75-76, 2001.
• Chua F. Paravertebral abscess. Clinical picture. Lancet 357 (9251): 168, 2001.

• Leach R and Chua F. Diffuse parenchymal (interstitial lung) diseases. In: Oxford Desk Reference in Acute Medicine. Oxford: Oxford University Press, 2010/11.
• Chua F, Laurent GJ, Gauldie J and Kolb M. Animal models of interstitial lung disease. In: Schwarz MI and King Jr TE, eds. Interstitial lung disease. 5th Edition. Ontario: BC Decker Inc., 2010.
• Chua F, Shah P. Haemoptysis. In: Waldmann C, Soni N, eds. Oxford Desk Reference in Critical Care, eds. Oxford: Oxford University Press, 2008.
• Chua F and Laurent GJ. Fibroblasts. In: Laurent GJ and Shapiro SD, eds. Encyclopedia of Pulmonary Medicine. New York: Academic Press Inc., 2006.